MAGT1

Across TCGA pan-cancer cohorts, MAGT1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MAGT1 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher MAGT1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAGT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, HNSC, and BLCA are the cancer types where MAGT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.082	0.564	.002	36	view →
HNSC	OS	Median	II,III,IV	0.058	0.712	<.001	24	view →
BLCA	OS	Median	All	0.197	0.720	.004	15	view →
UCEC	DFS	Median	All	0.961	0.622	.010	12	view →
SKCM	OS	Median	III,IV	0.358	0.727	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MAGT1–SCLC (DFS)

Open the SCLC breakdown →