MAGT1

Across TCGA patient cohorts, MAGT1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGT1-associated genes across cancer lineages are ACC1, JNK_pT183_Y185, and mTOR_pS2448. Each is linked with MAGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGT1-to-partner and partner-to-MAGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by MAGT1-low versus MAGT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGT1→partner) and Y-score (partner→MAGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.294	+1.887	.022	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.172	-1.906	.003	.015	3	2
UCEC	mTOR_pS2448 →	-0.120	-1.362	.022	.037	3	2
UCEC	P-Cadherin →	-0.136	-2.690	.007	.006	3	2
UCEC	Shc_pY317 →	-0.145	-2.700	.006	.006	3	2
UCEC	STAT3_pY705 →	-0.401	-1.678	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ACC1 by MAGT1 expression — UCEC

Explore this box plot interactively →