MAGOHB

Across TCGA pan-cancer cohorts, MAGOHB RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MAGOHB data layer compared with 1 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAGOHB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAGOHB expression acts as an unfavorable survival marker, although some lineages such as OV and READ show a favorable association.

KIRC, OV, and ACC are the cancer types where MAGOHB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.240	0.618	<.001	126	view →
OV	OS	Median	All	0.385	0.252	<.001	112	view →
ACC	OS	Quartile	All	0.385	0.836	<.001	78	view →
UVM	DFS	Quartile	II,III,IV	0.240	0.713	.001	74	view →
BRCA	OS	Tertile	All	0.901	0.954	.002	60	view →
MESO	OS	Median	All	0.405	0.674	<.001	51	view →
LIHC	OS	Tertile	III,IV	0.232	0.697	<.001	40	view →
KIRP	DFS	Tertile	All	0.612	0.817	<.001	39	view →
SARC	DFS	Median	All	0.513	0.704	<.001	38	view →
PAAD	OS	Median	All	0.508	0.756	.002	36	view →
LUAD	OS	Tertile	All	0.262	0.489	<.001	34	view →
LGG	OS	Median	All	0.862	0.927	<.001	33	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MAGOHB–KIRC (DFS)

Open the KIRC breakdown →