MAGOH

Across TCGA patient cohorts, MAGOH mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGOH-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and STAT3_pY705. Each is linked with MAGOH in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGOH-to-partner and partner-to-MAGOH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MAGOH-low versus MAGOH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGOH→partner) and Y-score (partner→MAGOH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.215	-3.000	.006	.036	3	1
UCEC	Notch1 →	+0.174	+2.183	.008	.033	3	1
UCEC	STAT3_pY705 →	-0.503	-2.584	<.001	.011	3	1
UCEC	VHL →	-0.850	-2.321	.007	.034	3	1
UCEC	ASNS →	+0.589	+2.999	<.001	.035	3	1
UCEC	ATM →	-0.701	-2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK_pT183_Y185 by MAGOH expression — UCEC

Explore this box plot interactively →