MAGIX

Across TCGA patient cohorts, MAGIX mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGIX-associated genes across cancer lineages are eEF2, 14-3-3_beta, and EGFR_pY1068. Each is linked with MAGIX in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGIX-to-partner and partner-to-MAGIX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MAGIX-low versus MAGIX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGIX→partner) and Y-score (partner→MAGIX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.476	+3.700	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.094	-2.558	.007	.010	3	1
UCEC	EGFR_pY1068 →	-0.249	-1.362	.004	.037	3	1
UCEC	eIF4E →	+0.252	+2.874	<.001	<.001	3	1
UCEC	eIF4G →	+0.282	+1.662	.010	.011	3	1
UCEC	A-Raf_pS299 →	-0.152	-1.807	<.001	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by MAGIX expression — UCEC

Explore this box plot interactively →