MAGI3

Across TCGA pan-cancer cohorts, MAGI3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MAGI3 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MAGI3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MAGI3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where MAGI3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.657	0.264	.016	17	view →
LUAD	OS	Tertile	All	0.833	0.597	.017	9	view →
CCRCC	DFS	Tertile	II,III,IV	0.836	1.000	.014	6	view →
HNSC	DFS	Tertile	All	0.861	0.678	.029	2	view →
UCEC	OS	Quartile	All	1.000	0.854	.019	2	view →
LSCC	OS	Tertile	All	1.000	0.684	.031	2	view →
GBM	DFS	Median	All	0.794	0.699	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MAGI3–PDAC (OS)

Open the PDAC breakdown →