MAGI3

Across TCGA patient cohorts, MAGI3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,585 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MAGI3-associated genes across cancer lineages are PIK3R3, S1PR2, and CYP4Z1. Each is linked with MAGI3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAGI3-to-partner and partner-to-MAGI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAGI3 versus PIK3R3 in CCRCC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI3→partner) and Y-score (partner→MAGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PIK3R3 →	+0.766	+0.406	<.001	<.001	3	4
OV	S1PR2 →	-0.767	-0.315	.002	.002	3	4
BRCA	CYP4Z1 →	+1.900	+0.237	.002	.004	3	4
LSCC	SLC5A9 →	+0.508	+0.320	<.001	<.001	3	4
BRCA	KIF12 →	+1.838	+0.310	<.001	.002	3	4
BRCA	SLC40A1 →	+1.464	+0.280	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,585 associations by consensus.

MAGI3 vs PIK3R3 — CCRCC

Explore this scatter interactively →