MAGI3

Across TCGA patient cohorts, MAGI3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGI3-associated genes across cancer lineages are PKC-a, FOXO3a_pS318_S321, and PCNA. Each is linked with MAGI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGI3-to-partner and partner-to-MAGI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a grouped by MAGI3-low versus MAGI3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI3→partner) and Y-score (partner→MAGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PKC-a →	-0.441	-3.169	.006	.019	3	2
UCEC	FOXO3a_pS318_S321 →	-0.086	-1.575	.033	.034	3	2
SKCM	PCNA →	+0.275	+2.321	.004	.035	3	2
UCEC	PDCD4 →	-0.350	-1.405	.021	.043	3	2
SKCM	TFRC →	+0.807	+3.000	.003	.034	3	2
UCEC	ATM →	-0.429	-2.209	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PKC-a by MAGI3 expression — BLCA

Explore this box plot interactively →