MAGI3

Across TCGA cell cohorts, MAGI3 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGI3-associated genes across cancer lineages are CEP57L1, BTNL2, and P2RY13. Each is linked with MAGI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGI3-to-partner and partner-to-MAGI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP57L1 grouped by MAGI3-low versus MAGI3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI3→partner) and Y-score (partner→MAGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP57L1 →	+0.611	+2.588	.001	.004	3	2
LARGE_INTESTINE	BTNL2 →	+0.028	+2.678	.002	.005	3	2
PANCREAS	P2RY13 →	+0.006	+4.491	<.001	.003	3	1
BONE	FAM90A26 →	+0.011	+4.000	<.001	.008	3	1
BONE	ARMH2 →	+0.057	+4.672	<.001	.001	3	1
BONE	TP53TG3E →	+0.107	+4.169	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

CEP57L1 by MAGI3 expression — LARGE_INTESTINE

Explore this box plot interactively →