Across TCGA patient cohorts, MAGI2 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGI2-associated genes across cancer lineages are c-Kit, Caspase-7-cleavedD198, and PRDX1. Each is linked with MAGI2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAGI2-to-partner and partner-to-MAGI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI2→partner) and Y-score (partner→MAGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	c-Kit →	-0.421	-3.000	.048	.035	3	4
UCEC	Caspase-7-cleavedD198 →	+0.445	+1.382	.010	.021	3	4
LUAD	PRDX1 →	+0.247	+3.016	.035	.018	3	3
COAD	GSK-3a-b_pS21_S9 →	-0.430	-2.144	.001	.003	3	3
UCEC	Notch1 →	+0.122	+1.594	.003	.010	3	3
UCEC	ATM →	-0.514	-2.736	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Exploration

MAGI2 survival (RNA) · tumor vs normal (RNA) · all MAGI2 data types