Across TCGA cell cohorts, MAGI2 mutation is significantly associated with the RNA expression of many other genes, with 838 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGI2-associated genes across cancer lineages are TNP1, DMRTB1, and ENPP7. Each is linked with MAGI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGI2-to-partner and partner-to-MAGI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI2→partner) and Y-score (partner→MAGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TNP1 →	+1.110	+4.369	<.001	.008	3	2
SOFT_TISSUE	DMRTB1 →	+0.045	+4.417	<.001	.004	3	2
SOFT_TISSUE	ENPP7 →	+0.004	+4.369	<.001	.008	3	2
SKIN	FCN2 →	+0.025	+3.700	<.001	.009	3	2
LUNG_NSCLC_LUAD	CTXN3 →	+0.037	+3.628	<.001	.002	3	2
LARGE_INTESTINE	INTS10 →	+0.699	+3.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 838 associations by consensus.

Exploration

MAGI2 survival (RNA) · tumor vs normal (RNA) · all MAGI2 data types