MAGI1-IT1

Across TCGA pan-cancer cohorts, MAGI1-IT1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MAGI1-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAGI1-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAGI1-IT1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

KIRC, ACC, and KIRP are the cancer types where MAGI1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.393	0.628	<.001	102	view →
ACC	DFS	Quartile	All	0.266	0.655	.001	76	view →
KIRP	DFS	Tertile	All	0.673	1.000	<.001	46	view →
LGG	DFS	Median	All	0.661	0.785	<.001	45	view →
DLBC	OS	Quartile	All	0.386	0.888	.001	38	view →
READ	OS	Median	All	0.788	1.000	<.001	25	view →
BRCA	DFS	Median	II,III,IV	0.956	0.925	.010	18	view →
SKCM	OS	Median	II,III,IV	0.862	0.643	.003	14	view →
COAD	OS	Tertile	III,IV	0.730	0.384	.006	9	view →
LUAD	OS	Median	All	0.849	0.733	.010	9	view →
SARC	DFS	Quartile	All	0.509	0.684	.008	9	view →
LIHC	OS	Median	III,IV	0.628	0.199	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MAGI1-IT1–KIRC (DFS)

Open the KIRC breakdown →