MAGEL2

Across TCGA pan-cancer cohorts, MAGEL2 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated MAGEL2 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher MAGEL2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEL2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

THYM, DLBC, and BRCA are the cancer types where MAGEL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
DLBC	DFS	Median	II,III,IV	0.076	0.809	<.001	30	view →
BRCA	OS	Median	II,III,IV	0.278	0.914	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ACC	OS	Median	All	0.268	0.802	.010	12	view →
STAD	OS	Median	II,III,IV	0.184	0.710	.001	12	view →
COAD	OS	Median	II,III,IV	0.145	0.655	.002	11	view →
SARC	OS	Median	All	0.029	0.828	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	DFS	Median	II,III,IV	0.178	0.721	.008	6	view →
READ	OS	Median	All	0.652	0.828	.048	3	view →
SKCM	DFS	Median	III,IV	0.680	0.198	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

MAGEL2–THYM (OS)

Open the THYM breakdown →