MAGEL2

Across TCGA patient cohorts, MAGEL2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEL2-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and VEGFR2. Each is linked with MAGEL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAGEL2-to-partner and partner-to-MAGEL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MAGEL2-low versus MAGEL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEL2→partner) and Y-score (partner→MAGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.370	+1.906	.001	.015	3	4
UCEC	Caspase-7-cleavedD198 →	+0.500	+1.341	.010	.043	3	4
LUSC	VEGFR2 →	-0.222	-2.321	.016	.031	3	3
UCEC	INPP4B →	-0.246	-2.999	.020	<.001	3	3
UCEC	Shc_pY317 →	-0.206	-1.938	<.001	.001	3	3
UCEC	ATM →	-0.576	-1.938	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ASNS by MAGEL2 expression — UCEC

Explore this box plot interactively →