MAGEL2

Across TCGA cell cohorts, MAGEL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,767 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MAGEL2-associated GO terms across cancer lineages are Regulation of transcription elongation by RNA polymerase II, Regulation of DNA-templated transcription elongation, and Spliceosomal snRNP assembly. Each is linked with MAGEL2 in more than 6 cancer types. Because this analysis shows association rather than direction, both MAGEL2-to-partner and partner-to-MAGEL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription elongation by RNA polymerase II grouped by MAGEL2-low versus MAGEL2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEL2→partner) and Y-score (partner→MAGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of transcription elongation by RNA polymerase II →	+0.060	+1.323	<.001	.003	3	7
LUNG_SCLC	Regulation of DNA-templated transcription elongation →	+0.049	+0.820	<.001	.001	3	6
LUNG_SCLC	Spliceosomal snRNP assembly →	+0.082	+1.208	<.001	.001	2	6
LUNG_SCLC	Transcription preinitiation complex assembly →	+0.060	+1.052	<.001	.003	3	5
SOFT_TISSUE	Gamma-aminobutyric acid signaling pathway →	-0.213	-1.398	<.001	.001	3	5
BONE	Spontaneous synaptic transmission →	+1.115	+0.473	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,767 associations by consensus.

Regulation of transcription elongation by RNA polymerase II by MAGEL2 expression — LUNG_SCLC

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