MAGEL2

Across TCGA cell cohorts, MAGEL2 mutation is significantly associated with the RNA expression of many other genes, with 239 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEL2-associated genes across cancer lineages are UCN3, C5orf49, and GPR63. Each is linked with MAGEL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEL2-to-partner and partner-to-MAGEL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCN3 grouped by MAGEL2-low versus MAGEL2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEL2→partner) and Y-score (partner→MAGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	UCN3 →	+0.023	+5.169	<.001	.004	3	2
BLOOD_Leukemia	C5orf49 →	+0.043	+4.152	<.001	.009	3	2
LARGE_INTESTINE	GPR63 →	+0.770	+3.212	.001	.006	3	2
LUNG_SCLC	DSPP →	+0.054	+3.222	<.001	.007	3	2
BONE	OR51I1 →	+0.303	+5.169	<.001	.004	3	1
BONE	OR5AU1 →	+0.023	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 239 associations by consensus.

UCN3 by MAGEL2 expression — BONE

Explore this box plot interactively →