MAGED2

Across TCGA patient cohorts, MAGED2 mutation is significantly associated with the RNA expression of many other genes, with 3,171 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGED2-associated genes across cancer lineages are SSX8P, EEF1A1P40, and ESS2. Each is linked with MAGED2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGED2-to-partner and partner-to-MAGED2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX8P grouped by MAGED2-low versus MAGED2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGED2→partner) and Y-score (partner→MAGED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SSX8P →	+0.312	+3.760	<.001	.007	3	2
CESC	EEF1A1P40 →	+0.041	+4.559	<.001	.006	3	2
UCEC	ESS2 →	+0.279	+1.885	<.001	<.001	3	2
UCEC	CENPM →	+0.525	+1.678	<.001	<.001	3	2
UCEC	GZMB →	+0.811	+1.874	.002	<.001	3	2
UCEC	PSMA3 →	+0.340	+2.567	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,171 associations by consensus.

SSX8P by MAGED2 expression — CESC

Explore this box plot interactively →