MAGED2

Across TCGA patient cohorts, MAGED2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MAGED2-associated genes across cancer lineages are EGFR_pY1068, p21, and PCNA. Each is linked with MAGED2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGED2-to-partner and partner-to-MAGED2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MAGED2-low versus MAGED2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGED2→partner) and Y-score (partner→MAGED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.391	-3.169	.005	.017	3	2
UCEC	p21 →	+0.124	+1.125	.032	.033	3	2
UCEC	PCNA →	+0.173	+1.662	.008	.010	3	2
UCEC	ARID1A →	-0.156	-1.404	.006	.043	3	2
UCEC	ATM →	-0.468	-2.571	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.242	+1.795	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

EGFR_pY1068 by MAGED2 expression — COAD

Explore this box plot interactively →