MAGED2

Across TCGA cell cohorts, MAGED2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAGED2-associated genes across cancer lineages are SPATA48, DPT, and C16orf92. Each is linked with MAGED2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGED2-to-partner and partner-to-MAGED2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by MAGED2-low versus MAGED2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGED2→partner) and Y-score (partner→MAGED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPATA48 →	+0.838	+3.544	<.001	.008	3	2
BLOOD_Leukemia	DPT →	+1.849	+4.091	<.001	.002	3	1
BLOOD_Leukemia	C16orf92 →	+0.194	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	OR13J1 →	+0.164	+4.096	<.001	.001	3	1
BLOOD_Leukemia	TMEM196 →	+0.036	+4.289	<.001	<.001	3	1
BLOOD_Leukemia	VWC2L →	+0.009	+3.339	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

SPATA48 by MAGED2 expression — BLOOD_Leukemia

Explore this box plot interactively →