MAGED1

Across TCGA patient cohorts, MAGED1 mutation is significantly associated with the RNA expression of many other genes, with 3,932 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGED1-associated genes across cancer lineages are IGHD1-1, MIR4515, and MIR8068. Each is linked with MAGED1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAGED1-to-partner and partner-to-MAGED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD1-1 grouped by MAGED1-low versus MAGED1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGED1→partner) and Y-score (partner→MAGED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IGHD1-1 →	+1.595	+4.409	.001	.006	3	3
CESC	MIR4515 →	+0.286	+5.569	<.001	.002	3	3
BRCA	MIR8068 →	+0.435	+4.473	<.001	.001	3	2
UCEC	CCL5 →	+0.972	+2.060	<.001	<.001	3	2
UCEC	SRCIN1 →	-0.501	-1.522	<.001	.003	3	2
CHOL	HINT1P2 →	+0.260	+5.087	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,932 associations by consensus.

IGHD1-1 by MAGED1 expression — CESC

Explore this box plot interactively →