MAGED1

Across TCGA patient cohorts, MAGED1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGED1-associated genes across cancer lineages are 14-3-3_beta, JNK2, and MEK1. Each is linked with MAGED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGED1-to-partner and partner-to-MAGED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MAGED1-low versus MAGED1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGED1→partner) and Y-score (partner→MAGED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.183	-2.433	.039	.020	3	2
COAD	JNK2 →	+0.265	+2.467	<.001	.011	3	2
UCEC	MEK1 →	+0.416	+1.857	<.001	<.001	3	2
COAD	Shc_pY317 →	-0.207	-2.983	.004	.034	3	2
COAD	Caspase-7-cleavedD198 →	+0.987	+3.321	.003	.009	3	2
UCEC	4E-BP1 →	+0.369	+1.857	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

14-3-3_beta by MAGED1 expression — COAD

Explore this box plot interactively →