MAGED1

Across TCGA cell cohorts, MAGED1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAGED1-associated genes across cancer lineages are NEUROG1, RAD51AP2, and MT1B. Each is linked with MAGED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGED1-to-partner and partner-to-MAGED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROG1 grouped by MAGED1-low versus MAGED1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGED1→partner) and Y-score (partner→MAGED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NEUROG1 →	+0.015	+5.022	<.001	.002	3	2
BLOOD_Leukemia	RAD51AP2 →	+0.043	+3.455	<.001	.002	3	2
SKIN	MT1B →	+0.076	+4.415	<.001	.007	3	1
SKIN	IGFL3 →	+0.952	+4.095	<.001	.009	3	1
SKIN	OR51A4 →	+0.010	+5.022	<.001	.002	3	1
SKIN	OR6X1 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

NEUROG1 by MAGED1 expression — SKIN

Explore this box plot interactively →