MAGEC3

Across TCGA patient cohorts, MAGEC3 mutation is significantly associated with the RNA expression of many other genes, with 5,723 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEC3-associated genes across cancer lineages are TMEM135, SCNN1B, and PHF5A. Each is linked with MAGEC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAGEC3-to-partner and partner-to-MAGEC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM135 grouped by MAGEC3-low versus MAGEC3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC3→partner) and Y-score (partner→MAGEC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TMEM135 →	+0.274	+1.751	.009	.002	3	5
LUAD	SCNN1B →	-1.023	-2.688	.005	.005	3	5
UCEC	PHF5A →	+0.459	+1.758	<.001	<.001	3	4
UCEC	PSMA3 →	+0.303	+1.765	<.001	<.001	3	4
UCEC	AHSA1 →	+0.317	+2.179	<.001	<.001	3	4
UCEC	PSMC1 →	+0.305	+1.665	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,723 associations by consensus.

TMEM135 by MAGEC3 expression — LUSC

Explore this box plot interactively →