MAGEC3

Across TCGA cell cohorts, MAGEC3 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEC3-associated genes across cancer lineages are OR2L8, OR2M4, and OR2H1. Each is linked with MAGEC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEC3-to-partner and partner-to-MAGEC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by MAGEC3-low versus MAGEC3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC3→partner) and Y-score (partner→MAGEC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2L8 →	+0.038	+4.450	<.001	.004	3	2
OVARY	OR2M4 →	+0.070	+4.700	<.001	.002	3	1
OVARY	OR2H1 →	+0.019	+4.029	.003	.009	3	1
LUNG_NSCLC_LUAD	SIGLEC9 →	+0.113	+3.628	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR10K1 →	+0.004	+3.362	<.001	.007	3	1
LUNG_SCLC	OR4S1 →	+0.016	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

OR2L8 by MAGEC3 expression — OVARY

Explore this box plot interactively →