MAGEC2

Across TCGA patient cohorts, MAGEC2 mutation is significantly associated with the RNA expression of many other genes, with 3,562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEC2-associated genes across cancer lineages are TXNP3, RPS2P39, and MIR5583-1. Each is linked with MAGEC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAGEC2-to-partner and partner-to-MAGEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNP3 grouped by MAGEC2-low versus MAGEC2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC2→partner) and Y-score (partner→MAGEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TXNP3 →	+0.092	+2.256	.003	.004	3	4
UCS	RPS2P39 →	+0.136	+4.584	<.001	.003	3	3
OV	MIR5583-1 →	+0.503	+5.475	<.001	.005	3	3
LUSC	SMS →	+0.810	+3.330	<.001	.005	3	3
UCEC	RPS6KB1 →	+0.369	+1.893	.002	<.001	3	3
LUSC	FAM199X →	+0.443	+2.942	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,562 associations by consensus.

TXNP3 by MAGEC2 expression — LUSC

Explore this box plot interactively →