MAGEC2

Across TCGA patient cohorts, MAGEC2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEC2-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and Caspase-7-cleavedD198. Each is linked with MAGEC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAGEC2-to-partner and partner-to-MAGEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by MAGEC2-low versus MAGEC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC2→partner) and Y-score (partner→MAGEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.111	-1.700	.005	.040	3	3
UCEC	Ku80 →	+0.170	+1.302	.024	.015	3	3
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.522	.001	.017	3	3
LUSC	IGFBP2 →	-1.015	-3.459	.002	.005	3	2
LUSC	Raptor →	+0.195	+3.183	.032	.009	3	2
UCEC	Cyclin-B1 →	+0.529	+2.222	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

FOXO3a_pS318_S321 by MAGEC2 expression — UCEC

Explore this box plot interactively →