MAGEC2

Across TCGA cell cohorts, MAGEC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,114 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MAGEC2-associated GO terms across cancer lineages are Regulation of response to endoplasmic reticulum stress, Positive regulation of type 2 mitophagy, and Maintenance of protein location in cell. Each is linked with MAGEC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both MAGEC2-to-partner and partner-to-MAGEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of response to endoplasmic reticulum stress grouped by MAGEC2-low versus MAGEC2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC2→partner) and Y-score (partner→MAGEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of response to endoplasmic reticulum stress →	+0.035	+1.504	.001	.001	3	7
BONE	Positive regulation of type 2 mitophagy →	+0.130	+2.840	.003	.009	3	6
BREAST	Maintenance of protein location in cell →	+0.088	+2.158	<.001	<.001	3	6
STOMACH	Membrane protein proteolysis →	+0.117	+2.306	<.001	.002	3	6
STOMACH	Activation of transmembrane receptor protein tyrosine kinase activity →	-0.200	-1.912	.002	.002	3	6
BREAST	Maintenance of protein location →	+0.091	+2.161	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,114 associations by consensus.

Regulation of response to endoplasmic reticulum stress by MAGEC2 expression — BREAST

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