MAGEC2

Across TCGA cell cohorts, MAGEC2 mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEC2-associated genes across cancer lineages are LCL161, Fludarabine, and Teniposide. Each is linked with MAGEC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEC2-to-partner and partner-to-MAGEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by MAGEC2-low versus MAGEC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC2→partner) and Y-score (partner→MAGEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.425	+2.646	.008	.047	2	2
LARGE_INTESTINE	Fludarabine →	+0.554	+2.649	.037	.046	3	1
LARGE_INTESTINE	Teniposide →	+0.560	+2.649	.036	.046	2	1
LARGE_INTESTINE	50869 →	+0.486	+2.649	.021	.046	2	1
LARGE_INTESTINE	AZD1208 →	+0.406	+2.649	.018	.046	1	1
LARGE_INTESTINE	Wnt-C59 →	+0.380	+2.646	.030	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

LCL161 by MAGEC2 expression — LARGE_INTESTINE

Explore this box plot interactively →