MAGEC1

Across TCGA patient cohorts, MAGEC1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEC1-associated genes across cancer lineages are JNK_pT183_Y185, 4E-BP1, and Caspase-7-cleavedD198. Each is linked with MAGEC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAGEC1-to-partner and partner-to-MAGEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MAGEC1-low versus MAGEC1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC1→partner) and Y-score (partner→MAGEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	JNK_pT183_Y185 →	-0.120	-1.974	.023	.029	3	4
UCEC	4E-BP1 →	+0.221	+1.292	.001	.010	3	4
UCEC	Caspase-7-cleavedD198 →	+0.332	+1.157	.027	.024	3	4
STAD	ATM →	-0.378	-3.807	.006	<.001	3	3
BLCA	STAT3_pY705 →	-0.295	-2.999	.015	.035	3	3
UCEC	eIF4E →	+0.131	+1.598	.014	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

JNK_pT183_Y185 by MAGEC1 expression — LUAD

Explore this box plot interactively →