MAGEC1

Across TCGA cell cohorts, MAGEC1 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEC1-associated genes across cancer lineages are DUXA, SYCP1, and DIP2C-AS1. Each is linked with MAGEC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAGEC1-to-partner and partner-to-MAGEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUXA grouped by MAGEC1-low versus MAGEC1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEC1→partner) and Y-score (partner→MAGEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DUXA →	+0.047	+3.196	<.001	.004	3	3
SOFT_TISSUE	SYCP1 →	+0.045	+3.865	<.001	.006	3	2
BLOOD_Leukemia	DIP2C-AS1 →	+0.093	+3.218	.008	.004	3	2
LUNG_NSCLC_LUAD	EFCAB9 →	+0.037	+2.714	<.001	.007	3	2
LARGE_INTESTINE	THNSL1 →	+0.731	+3.364	.001	.002	3	2
LARGE_INTESTINE	RPS4X →	+0.572	+3.067	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

DUXA by MAGEC1 expression — CNS

Explore this box plot interactively →