MAGEB6

Across TCGA cell cohorts, MAGEB6 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEB6-associated genes across cancer lineages are PLPPR1, OR10A4, and OR4F21. Each is linked with MAGEB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEB6-to-partner and partner-to-MAGEB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLPPR1 grouped by MAGEB6-low versus MAGEB6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEB6→partner) and Y-score (partner→MAGEB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLPPR1 →	+0.656	+3.285	<.001	.008	3	1
LARGE_INTESTINE	OR10A4 →	+0.056	+4.201	<.001	<.001	3	1
LARGE_INTESTINE	OR4F21 →	+0.168	+2.878	<.001	.009	3	1
LARGE_INTESTINE	OOSP4A →	+0.102	+3.115	<.001	.004	3	1
LUNG_NSCLC_LUAD	G6PC →	+0.052	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.012	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PLPPR1 by MAGEB6 expression — LARGE_INTESTINE

Explore this box plot interactively →