MAGEB2

Across TCGA patient cohorts, MAGEB2 mutation is significantly associated with the RNA expression of many other genes, with 3,185 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEB2-associated genes across cancer lineages are SAC3D1, SF3B5, and ATPAF2. Each is linked with MAGEB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAGEB2-to-partner and partner-to-MAGEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAC3D1 grouped by MAGEB2-low versus MAGEB2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEB2→partner) and Y-score (partner→MAGEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SAC3D1 →	+0.465	+2.906	.003	.001	3	3
LUSC	SF3B5 →	+0.432	+2.628	<.001	.005	3	3
UCEC	ATPAF2 →	+0.366	+1.847	<.001	<.001	3	3
LUSC	HPF1 →	+0.417	+2.918	.002	.001	3	3
LUSC	HSD17B10 →	+0.402	+3.459	.002	.005	3	3
UCEC	CDC34 →	+0.447	+4.108	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,185 associations by consensus.

SAC3D1 by MAGEB2 expression — LUSC

Explore this box plot interactively →