MAGEB2

Across TCGA patient cohorts, MAGEB2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEB2-associated genes across cancer lineages are EGFR_pY1068, SCD, and PCNA. Each is linked with MAGEB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAGEB2-to-partner and partner-to-MAGEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MAGEB2-low versus MAGEB2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEB2→partner) and Y-score (partner→MAGEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	EGFR_pY1068 →	-0.418	-3.000	.048	.035	3	3
LUSC	SCD →	-0.148	-2.972	.001	.035	3	3
UCEC	PCNA →	+0.226	+2.700	.002	.005	3	3
UCEC	Rab25 →	-0.395	-3.000	<.001	<.001	3	3
UCEC	ATM →	-0.550	-1.736	<.001	.007	3	3
LUSC	Bid →	+0.169	+2.179	.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by MAGEB2 expression — LUSC

Explore this box plot interactively →