MAGEB2

Across TCGA cell cohorts, MAGEB2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAGEB2-associated genes across cancer lineages are SIRPD, PDHA2, and GOLGA6L1. Each is linked with MAGEB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEB2-to-partner and partner-to-MAGEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRPD grouped by MAGEB2-low versus MAGEB2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEB2→partner) and Y-score (partner→MAGEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIRPD →	+0.058	+5.029	<.001	.006	3	1
LUNG_SCLC	PDHA2 →	+0.033	+5.029	<.001	.006	3	1
SKIN	GOLGA6L1 →	+0.013	+4.684	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	SMR3A →	+0.049	+4.736	.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRT73 →	+0.065	+4.215	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SIRPD by MAGEB2 expression — LUNG_SCLC

Explore this box plot interactively →