Across TCGA pan-cancer cohorts, MAGEA9 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MAGEA9’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MAGEA9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAGEA9 is over-expressed in tumor.
LUSC are the cancer types where MAGEA9 tumor–normal differential expression is most reproducible.