Across TCGA pan-cancer cohorts, MAGEA6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MAGEA6 data layer compared with 20 for mass-spec protein.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MAGEA6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAGEA6 expression acts as an unfavorable survival marker.
BLCA, BRCA, and COAD are the cancer types where MAGEA6 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.