Across TCGA patient cohorts, MAGEA6 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEA6-associated genes across cancer lineages are 14-3-3_beta, VHL, and MEK1_p_S217_S221. Each is linked with MAGEA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA6-to-partner and partner-to-MAGEA6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA6→partner) and Y-score (partner→MAGEA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.126	-3.446	.012	.005	3	1
UCEC	VHL →	-0.814	-3.000	.016	.036	3	1
SKCM	MEK1_p_S217_S221 →	-0.200	-1.906	.033	.016	3	1
SKCM	SETD2 →	-0.122	-1.906	.033	.016	3	1
UCEC	MEK1 →	+0.432	+3.459	.018	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

MAGEA6 survival (RNA) · tumor vs normal (RNA) · all MAGEA6 data types