MAGEA4

Across TCGA pan-cancer cohorts, MAGEA4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MAGEA4 data layer compared with 14 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MAGEA4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAGEA4 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

HNSC, OV, and LUAD are the cancer types where MAGEA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.153	0.798	.017	14	view →
OV	DFS	Median	All	0.870	0.574	.046	4	view →
LUAD	OS	Quartile	All	0.398	1.000	.018	3	view →
LSCC	OS	Quartile	II,III,IV	0.845	1.000	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MAGEA4–HNSC (DFS)

Open the HNSC breakdown →