MAGEA4

Across TCGA patient cohorts, MAGEA4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGEA4-associated genes across cancer lineages are PCNA, 4E-BP1_pS65, and 4E-BP1. Each is linked with MAGEA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA4-to-partner and partner-to-MAGEA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MAGEA4-low versus MAGEA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA4→partner) and Y-score (partner→MAGEA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.221	+3.000	.002	<.001	3	2
LUAD	4E-BP1_pS65 →	+0.246	+3.012	<.001	.018	3	2
LUAD	4E-BP1 →	+0.504	+3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.087	-2.088	.009	.016	3	2
UCEC	TFRC →	+0.503	+2.700	.004	.005	3	2
UCEC	ATM →	-0.641	-1.874	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PCNA by MAGEA4 expression — UCEC

Explore this box plot interactively →