Across TCGA pan-cancer cohorts, MAGEA12 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated MAGEA12 data layer compared with 23 for mass-spec protein.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher MAGEA12 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEA12 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
LUSC, UCEC, and TGCT are the cancer types where MAGEA12 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.