MAG

Across TCGA pan-cancer cohorts, MAG Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated MAG data layer compared with 20 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher MAG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAG expression acts as an unfavorable survival marker, although some lineages such as UCS show a favorable association.

THYM, BLCA, and ACC are the cancer types where MAG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	OS	Median	III,IV	0.120	0.684	<.001	30	view →
ACC	DFS	Median	All	0.057	0.667	<.001	15	view →
BRCA	DFS	Median	All	0.358	0.903	<.001	12	view →
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	All	0.293	0.720	.005	5	view →
SARC	OS	Median	All	0.140	0.513	.043	3	view →
UCS	DFS	Median	All	1.000	0.217	.023	2	view →
LGG	OS	Median	All	0.711	0.896	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

MAG–THYM (OS)

Open the THYM breakdown →