MAFB

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MAFB mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAFB-associated genes across cancer lineages are FOXO3a_pS318_S321, MAPK_pT202_Y204, and mTOR_pS2448. Each is linked with MAFB in more than 1 cancer types. Because this analysis shows association rather than direction, both MAFB-to-partner and partner-to-MAFB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAFB→partner) and Y-score (partner→MAFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECFOXO3a_pS318_S321 →-0.168-2.312<.001.00532
UCECMAPK_pT202_Y204 →-0.385-1.700.036.04232
UCECmTOR_pS2448 →-0.145-2.565.013.01032
UCECNotch1 →+0.121+1.584.028.03632
UCECPCNA →+0.189+1.584.026.03632
UCECPDCD4 →-0.546-2.000.003.01032
Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration