Across TCGA pan-cancer cohorts, MAFA Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated MAFA data layer compared with 27 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher MAFA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAFA expression acts as an unfavorable survival marker.

SCLC are the cancer types where MAFA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	IV	0.137	0.548	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: MAFA tumor-vs-normal RNA expression · all MAFA data types