MAFA

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MAFA RNA expression is significantly associated with the go_rna of many other GO terms, with 7,086 significant associations in total. UVM shows the largest number of these associations.

The most reproducible MAFA-associated GO terms across cancer lineages are DNA topological change, Regulation of muscle cell differentiation, and Negative regulation of Notch signaling pathway. Each is linked with MAFA in more than 13 cancer types. Because this analysis shows association rather than direction, both MAFA-to-partner and partner-to-MAFA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAFA→partner) and Y-score (partner→MAFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
ESCADNA topological change →+0.074+0.685<.001<.001314
UCSRegulation of muscle cell differentiation →+0.034+1.421<.001<.001314
UCSNegative regulation of Notch signaling pathway →+0.041+1.515.007<.001214
STADProtein insertion into ER membrane →+0.044+0.284<.001<.001313
TGCTObsolete DNA methylation on cytosine →+0.131+1.672<.001<.001313
UCSPositive regulation of muscle cell differentiation →+0.038+1.256<.001<.001312
Each partner links to its Q-omics profile. Showing the 6 strongest of 7,086 associations by consensus.

Exploration