Across TCGA cell cohorts, MAFA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,304 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MAFA-associated GO terms across cancer lineages are Positive regulation of stem cell population maintenance, Regulation of stem cell population maintenance, and RNA splicing, via transesterification reactions. Each is linked with MAFA in more than 10 cancer types. Because this analysis shows association rather than direction, both MAFA-to-partner and partner-to-MAFA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAFA→partner) and Y-score (partner→MAFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of stem cell population maintenance →	+0.073	+0.326	<.001	.001	3	11
LARGE_INTESTINE	Regulation of stem cell population maintenance →	+0.065	+0.358	<.001	.004	3	11
OESOPHAGUS	RNA splicing, via transesterification reactions →	+0.061	+0.931	.001	.002	3	11
OESOPHAGUS	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.060	+0.931	.001	.002	3	11
OESOPHAGUS	mRNA splicing, via spliceosome →	+0.060	+0.931	.001	.002	3	11
SOFT_TISSUE	Negative regulation of adaptive immune response →	-0.094	-0.785	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,304 associations by consensus.

Exploration

MAFA survival (RNA) · tumor vs normal (RNA) · all MAFA data types