MAF1

Across TCGA patient cohorts, MAF1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAF1-associated genes across cancer lineages are TRBV20OR9-2, MIR4422, and MIR6515. Each is linked with MAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAF1-to-partner and partner-to-MAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV20OR9-2 grouped by MAF1-low versus MAF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAF1→partner) and Y-score (partner→MAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRBV20OR9-2 →	+0.471	+5.357	<.001	.006	3	1
LUAD	MIR4422 →	+0.371	+7.930	<.001	.008	3	1
UCEC	MIR6515 →	+0.436	+4.335	<.001	.007	3	1
UCEC	MIR6750 →	+0.966	+4.298	<.001	.001	3	1
UCEC	MIR7976 →	+0.619	+3.453	.001	.009	3	1
UCEC	MIR6133 →	+0.626	+3.982	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

TRBV20OR9-2 by MAF1 expression — COAD

Explore this box plot interactively →