MAF

Across TCGA patient cohorts, MAF mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAF-associated genes across cancer lineages are PCNA, Rad50, and ATM. Each is linked with MAF in more than 1 cancer types. Because this analysis shows association rather than direction, both MAF-to-partner and partner-to-MAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MAF-low versus MAF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAF→partner) and Y-score (partner→MAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.279	+2.593	.007	.006	3	2
COAD	Rad50 →	-0.244	-2.974	.015	.035	3	2
COAD	ATM →	-0.562	-3.459	<.001	.005	3	2
UCEC	eIF4E →	+0.181	+3.013	.005	<.001	3	2
UCEC	FoxM1 →	+0.191	+1.263	.015	.019	3	2
UCEC	ACC_pS79 →	+0.264	+1.263	.012	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PCNA by MAF expression — COAD

Explore this box plot interactively →