MAF

Across TCGA cell cohorts, MAF mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible MAF-associated genes across cancer lineages are NEUROD4 and GLOD5. Each is linked with MAF in more than 1 cancer types. Because this analysis shows association rather than direction, both MAF-to-partner and partner-to-MAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD4 grouped by MAF-low versus MAF-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAF→partner) and Y-score (partner→MAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NEUROD4 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	GLOD5 →	+0.074	+4.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

NEUROD4 by MAF expression — BLOOD_Myeloma

Explore this box plot interactively →