MAEA

Across TCGA cell cohorts, MAEA mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAEA-associated genes across cancer lineages are CCDC105, FAM47A, and LIPN. Each is linked with MAEA in more than 1 cancer types. Because this analysis shows association rather than direction, both MAEA-to-partner and partner-to-MAEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC105 grouped by MAEA-low versus MAEA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAEA→partner) and Y-score (partner→MAEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCDC105 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	FAM47A →	+0.073	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	LIPN →	+0.037	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	LCE1F →	+0.066	+4.662	.001	.005	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+4.196	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.340	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CCDC105 by MAEA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →