MAD2L2

Across TCGA patient cohorts, MAD2L2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,207 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAD2L2-associated genes across cancer lineages are DRAXIN, PIMREG, and KIF2C. Each is linked with MAD2L2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAD2L2-to-partner and partner-to-MAD2L2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAD2L2 versus DRAXIN in GBM, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L2→partner) and Y-score (partner→MAD2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DRAXIN →	+0.865	+0.383	<.001	<.001	3	6
OV	PIMREG →	+1.236	+0.714	<.001	<.001	3	5
BRCA	KIF2C →	+1.205	+0.398	<.001	<.001	3	5
OV	SPAG5 →	+1.087	+0.655	.001	<.001	3	5
GBM	TRAF4 →	+0.626	+0.351	<.001	<.001	3	4
GBM	FBXO5 →	+0.987	+0.714	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,207 associations by consensus.

MAD2L2 vs DRAXIN — GBM

Explore this scatter interactively →